Coconut Oil and Cannabis Capsule – A Medical Miracle?

post-261681-13686183466374
 

Humans have cultivated and used the flowering tops of the female cannabis plant, known colloquially as marijuana, since history was recorded. Archaeologists in Central Asia even found over 2 pounds of cannabis in a 2,700 year-old grave of a shaman.

Written and pictorial evidence of cannabis use is scattered throughout numerous cultures indicating a wide acceptance and use of the plant for thousands of years.

Drug Classification Halts Use 

Federal prohibitions outlawing the therapeutic and recreational use of cannabis were first imposed by Congress with the Marijuana Tax Act of 1937. Later, the plant’s organic compounds (cannabinoids) were classified as a Schedule I substance under the Controlled Substances Act of 1970.

This classification puts the plant in the same pool as heroin and states that cannabis possesses “a high potential for abuse … no currently accepted medical use … [and] a lack of accepted safety for the use of the drug … under medical supervision.”

In contrast, cocaine and methamphetamine – illegal for recreational use, may be consumed under a doctors supervision and are classified as Schedule II drugs. Examples of Schedule III and IV drugs include anabolic steroids and Valium. Analgesics that contain codeine are defined by law as Schedule V drugs, the most lenient classification.

In Support of Therapeutic Use 

Federal lawmakers continue to use the dated drug classification as a means to defend criminalization of marijuana. However, there appears to be very little scientific basis for the categorization of the plant. As its prohibition has passed 75 years, researchers continue to study the therapeutic properties of cannabis.

There are over 20,000 published reviews and studies in scientific literature that pertain to the cannabis plant and its cannabinoids, almost one-third of these have been published in the last 4 years. A keyword search on PubMed Central (the US government library of peer-reviewed scientific research) shows 2,100 studies alone since 2011.

Modern culture is now catching up on what our ancestors knew, and public opinion and relaxing state legislation are leading the way for more people to use medicinal marijuana for a wide number of medical conditions. At present, marijuana for medical purposes is legal in 20 states and the District of Columbia.

While the debate continues to boil at both state and federal levels, there has been a strong and growing trend of acceptance related to the growing body of scientific evidence indicating that marijuana may indeed contain some powerful medicinal properties that we would be foolish to overlook.

Joycelyn Elders, MD, former US Surgeon General, wrote the following in a Mar. 26, 2004 article titled “Myths About Medical Marijuana,” published in the Providence Journal:
marijuana-capsule-300x300Testimony – A Success Story

While many remain suspicious of the therapeutic benefits of cannabis, Stan and Barb Rutner are convinced of its efficacy. This couple has stood in the face of cancer a number of times and survived to learn from their experiences.

Barb had two bouts of breast cancer and Stan was diagnosed 20 years ago with non-Hodgkin lymphoma which, after treatment, disappeared. However, in 2011, it returned. Cancerous nodes in his lungs were diagnosed and later he was told that the cancer was in his brain. The outlook was grim indeed.

As he went through the harsh treatment of chemotherapy and radiation, Stan and his family wanted to find a natural solution that would help improve his quality of life and even prolong it. Hearing that cannabis was effective in helping with the pain and other effects of chemotherapy for cancer patients they were more than open to give it a try. According to Stan and Barb, medical cannabis was the golden ticket.

The Rutners daughter, Corinne and her husband did some research and it was decided that daytime cannabis capsule infused in coconut oil would be a good choice. After two weeks of taking the capsule, Stan was able to give up his oxygen tank that he was tied to around the clock. He began to gain weight, sleep better and get stronger overall. After several months, a brain scan revealed that Stan was completely cancer free.

The Rutners are convinced that cannabis works as an anti-cancer medicine. According to John, the Rutners son-in-law, “There is no doubt in my mind that cannabis pulled my father-in-law out of the wasting stages of cancer and enabled him to gain strength and in turn fight this horrible cell malfunction with success. While many would say that the chemo and radiation could have played apart, he would never have lived long enough to find out without cannabis oil.”

Sources:
http://norml.org/component/zoo/category/recent-research-on-medical-marijuana
http://www.cmcr.ucsd.edu/
http://ireadculture.com/article-2940-convinced-of-the-cure.html
Source: thealternativedaily

Enjoy Thought Pursuits? LIKE US ON FB
Thought Pursuits

Thought Pursuits

ThoughtPursuits.com was created with the sole purpose of providing valuable and interesting information that will provoke its readers to get into a creative thinking process, with the aim to help them lead a better life.

More thought-provoking content...

  • Jerome Barry

    Anecdotes aren’t evidence.

    • Chris King

      Well personal experience is evidence. I know 5 people CURED only using marijuana extract

      • Marie

        I have two friends who did as well.

    • Maribel Crider

      and you are up for an abrupt awakening when you know that “evidence” by western medicine is not true…skewed and manipulated results are the daily bread. Wake up people!

      http://www.collective-evolution.com/2015/05/16/editor-in-chief-of-worlds-best-known-medical-journal-half-of-all-the-literature-is-false/

    • Marie

      What do you want….the precious PEER REVIEWED JOURNALS who “approved” drugs like Vioxx or Xarelto or any of the NUMEROUS other FDA approved drugs that harm and kill? You need those studies as evidence? Because you would then believe? Yeah….not me. I prefer anecdotes, especially the SHEER NUMBER of them I’ve read…. over ‘peer reviewed’ medical studies any day. :/

    • Jeff Quickle

      Did you know there are all sorts of Scholars? There are so-called biblical scholars who ONLY look for INFO that protects and supports their own PERSONAL beliefs. There are unbiased Scholars who seek and look for TRUTH and FACTS. This is a HUGE problem because many people ONLY look for info that backs up their beliefs and they will never know Truth or seek it. And when they see the term or title “scholar” and the info lines up with what they believe or have been taught by their parents and the preacher down the street, they are STUCK in that sad perspective their whole life, missing out on the facts and truths that exist all around them. You might be in this category….I Hope not!

  • Lesley Earl

    I’d accept antidotes that help…real hard to get the evidence when no one will make money from it so refuse to study it

    • Robert Ireland

      what the hell are you talking about? There are well around 40,000 abstracts and research reports at the NIH website and having pored through over 20,000 in the past 29 months I can inform you that is a total crock of shyte. In fact, your government has been paying Dr. Raphael Mechoulam, Head of the school of pharmacology at the University of Jerusalem for since the early 1960s, around $140,000 annually to keep researching and research he has. Evidence? Open your eyes, it’s everywhere! .

    • Kelly Dunn

      Smoke it, thats the evidence.

  • kauainaut

    The FDA approved Marinol years ago, which is made from marijuana. The marijuana laws are still used to control the American population, and are criminal themselves.

    • Karen Glammeyer Medcoff

      Marinol is a man-made form of cannabis NOT the actual good stuff itself. but man made garbage

      • kauainaut

        There is no such thing. You are looking at the definition of the word. All this means is it was processed in the laboratory like all medications. They START with marijuana.

        • jonathan

          Marino is not made from cannabis

        • Karen Glammeyer Medcoff

          marinol is SYNTHESIZED based on MJ it is NOT mj. the regular item is safer than the man made crap. BUT it doesn’t bring them money, so they created a synthetic BASED on a natural.

        • Karen Glammeyer Medcoff

          here is some light reading for you in case you really didn’t know it IS SYNTHETIC NOT MJ

          “Marinol1 (dronabinol) is the only US FDA-approved synthetic cannabinoid. It is often marketed as a legal pharmaceutical alternative to natural cannabis.

          Marinol is manufactured as a gelatin capsule containing synthetic delta-9-tetrahydrocannabinol (THC) in sesame oil. It is taken orally and is available in 2.5mg, 5mg and/or 10mg dosages. Marinol may be prescribed for the treatment of cachexia (weight loss) in patients with AIDS and for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments.

          Despite FDA approval2, Marinol typically provides only limited relief to select patients, particularly when compared to natural cannabis and its cannabinoids. Marinol should remain a legal option for patients and physicians; however, federal and state laws should be amended to allow for those patients who are unresponsive to synthetic THC the ability to use natural cannabis and its cannabinoids as a medical therapy without fear of arrest and/or criminal prosecution. By prohibiting the possession and use of natural cannabis and its cannabinoids, patients are unnecessarily restricted to use a synthetic substitute that lacks much of the therapeutic efficacy of natural cannabis.

          Marinol Lacks Several of the Therapeutic Compounds Available in Natural Cannabis

          Chemical compounds in cannabis, known as cannabinoids, are responsible for its numerous therapeutic benefits. Scientists have identified 66 naturally occurring cannabinoids.3

          The active ingredient in Marinol, synthetic delta-9-tetrahyrdocannabinol (THC), is an analogue of one such compound, THC. However, several other cannabinoids available in cannabis — in addition to naturally occurring terpenoids (oils) and flavonoids (phenols) — have also been clinically demonstrated to possess therapeutic utility. Many patients favor natural cannabis to Marinol because it includes these other therapeutically active cannabinoids.

          For example, cannabidol (CBD) is a non-psychoactive cannabinoid that has been clinically demonstrated to have analgesic, antispasmodic, anxiolytic, antipsychotic, antinausea, and anti-rheumatoid arthritic properties.4

          Animal and human studies have shown CBD to possess anti-convulsant properties, particularly in the treatment of epilepsy.5 Natural extracts of CBD, when administered in combination with THC, significantly reduce pain, spasticity and other symptoms in multiple sclerosis (MS) patients unresponsive to standard treatment medications.6

          Clinical studies also demonstrate CBD to be neuroprotective against glutamate neurotoxicity7 (i.e. stroke), cerebral infarction8 (localized cell death in the brain), and ethanol-induced neurotoxicity,9 with CBD being more protective against glutamate neurotoxicity than either ascorbate (vitamin C) or alpha-tocopherol (vitamin E).10 Clinical trials have also shown CBD to possess anti-tumoral properties,11inhibiting the growth of glioma (brain tumor) cells in a dose dependent manner and selectively inducing apoptosis (programmed cell death) in malignant cells.12

          Additional cannabinoids possessing clinically demonstrated therapeutic properties include: cannabinol (anticonvulsant13 and anti-inflammatory14 activity); cannabichromine (anti-inflammatory15 and antidepressant16 activity); and cannabigerol (anti-tumoral17 and analgesic18 activity). Natural cannabis’ essential oil components (terpenoids) exhibit anti-inflammatory properties19 and its flavonoids possess antioxidant activity.20 Emerging clinical evidence indicates that cannabinoids may slow disease progression21 in certain autoimmune and neurologic diseases, including multiple sclerosis22 (MS), Amyotrophic Lateral Sclerosis23 (Lou Gehrig’s disease) and Huntington’s Disease.24

          Clinical data indicate that the synergism of these compounds is likely more efficacious25 than the administration of synthetic THC alone.26 For example, McPartland and Russo write: “Good evidence shows that secondary compounds in cannabis may enhance beneficial effects of THC. Other cannabinoid and non-cannabinoid compounds in herbal cannabis … may reduce THC-induced anxiety, cholinergic deficits, and immunosuppression. Cannabis terpenoids and flavonoids may also increase cerebral blood flow, enhance cortical activity, kill respiratory pathogens, and provide anti-inflammatory activity.”27 In an in vitro model of epilepsy, natural cannabis extracts performed better than THC alone.28In human trials, patients suffering from multiple sclerosis experienced greater symptomatic relief from sublingual natural cannabis extracts than from the administration of oral THC.29 In 2005, Health Canada approved the oral spray Sativex30 — which contains precise ratios of the natural cannabinoid extracts THC and CBD, among other compounds — for prescription use for MS-related symptoms.31

          Marinol is More Psychoactive Than Natural Cannabis

          Patients prescribed Marinol frequently report that its psychoactive effects are far greater than those of natural cannabis. Marinol’s adverse effects include: feeling “high,” drowsiness, dizziness, confusion, anxiety, changes in mood, muddled thinking, perceptual difficulties, coordination impairment, irritability, and depression.32 These psychoactive effects may last four to six hours.33 About one-third of patients prescribed Marinol report experiencing one or some of these adverse effects.34

          Marinol’s oral route of administration is responsible, in part, for its heightened psychoactivity compared to inhaled cannabis. Once swallowed, Marinol passes from the stomach to the small intestine before being absorbed into the bloodstream. Following absorption, Marinol passes through the liver where a significant proportion of the drug is metabolized into other chemicals.35 One of these chemicals, 11-hydroxy-THC, may be four to five times more potent than natural THC,36 and is produced in greater quantities.37 Thus, patients administered Marinol experience the psychoactive effects of both THC and 11-hydroxy-THC, greatly increasing the likelihood that they will suffer from an adverse psychological reaction. By comparison, only minute quantities of 11-hydroxy-THC are produced when cannabis is inhaled.38 Moreover, Marinol lacks the compound cannabidiol, which possesses anxiolytic activity and likely modifies and/or diminishes much of THC’s psychoactivity in natural cannabis.39

          Cannabis Vaporization Offers Advantages Over Orally Administered THC

          Vaporization is an alternative method of cannabis administration that holds distinct advantages over both smoking and oral administration. Cannabis vaporization suppresses respiratory toxins by heating cannabis to a temperature where cannabinoid vapors form (typically around 180-190 degrees Celsius), but below the point of combustion where noxious smoke and associated toxins (i.e., carcinogenic hydrocarbons) are produced (near 230 degrees Celsius).40 Although a comprehensive review of cannabis and health conducted by the National Academy of Sciences Institute of Medicine found “no conclusive evidence that marijuana causes cancer in humans, including cancers usually related to tobacco use,”41 studies have found that heavy cannabis smokers face a higher risk of contracting bronchitis and respiratory illnesses.42This risk is likely not due to the inhalation of cannabinoids, but rather to the exposure of noxious smoke. Because vaporization can deliver therapeutic doses of cannabinoids while reducing the users intake of pyrolytic smoke compounds, it is considered to be a preferred and likely safer method of cannabis administration than smoking.43

          In practice, cannabis vaporization offers considerable advantages over oral THC consumption. While the oral ingestion of Marinol avoids the potential risks of smoking, it has significant drawbacks. Because of synthetic THC’s poor bioavailability, only 5-20 percent of an oral dose ever reaches the bloodstream44 and the drug may not achieve peak effect until four hours after dosing.45 Moreover, because Marinol is metabolized slowly, its therapeutic and psychoactive effects may be unpredictable and vary considerably, both from one person to another, and in the same person from one episode of use to another.46 By contrast, cannabis vaporization delivers cannabinoids to the bloodstream almost instantaneously.47Vaporization’s rapid onset also allows patients to self regulate their dosage of cannabinoids by immediately ceasing inhalation when/if their psychoactive effects become unpleasant.48After oral administration of Marinol, patients have no choice but to experience the full psychoactive effects of the dose consumed. These dysphoric effects may last several hours.

          Because of its rapid onset, vaporized cannabis is more desirable than Marinol for patients requiring a fast-acting therapeutic agent, such as those combating oncoming attacks of nausea, seizures or muscle spasms. Cannabis vaporization also offers a unique advantage to patients suffering from nausea and vomiting because it allows them an alternative delivery route to swallowing. Cancer and HIV/AIDS patients often report that their stomachs cannot hold down Marinol capsules during bouts of severe nausea49 and many rely on natural cannabis and cannabinoids for symptom control.50 In a 1994 survey of oncologists, respondents ranked synthetic THC ninth on a list of available antiemetic medications.51In another survey of oncologists, 44 percent of respondents said that they believed natural cannabis to be more efficacious than oral synthetic THC; only 13 percent of respondents rated Marinol more effective.52 A 1997 survey of physicians found that a majority preferred megestrol acetate over Marinol as an appetite stimulant in patients with HIV/AIDS.53

          As a result of Marinol’s slow onset and poor bioavailablity, scientists are now in the process of developing a new formulation of pulmonary dronabinol, delivered with a pressurized metered dose inhaler.54 In a Phase I study, pulmonary Marinol delivered via an inhaler provided rapid systemic absorption. Unlike oral synthetic THC, it’s possible that pulmonary Marinol “could offer an alternative for patients when a fast onset of action is desirable.”55 However, FDA approval of pulmonary Marinol and/or its inhaler remains years away. Sativex, an oral cannabis spray consisting of natural cannabinoid extracts, has greater bioavailability and is faster acting than oral synthetic THC. Clinical trials comparing its bioavailability and time of peak onset compared to vaporized cannabis have not been performed, though anecdotal reports indicate that vaporized cannabis and its cannabinoids likely possess greater bioavailability and are faster acting than the Sativex spray.

          Marinol is More Expensive Than Natural Cannabis

          Synthetic THC is a costly and difficult compound to manufacture.56 Much of this cost is passed on to the patient consumer, particularly if the full cost of Marinol (approximately $200 to $800 per month,57depending on the dosage) is borne out of pocket. Patients, particularly those with chronic conditions, often report that Marinol’s market cost limits their use of the drug.58 Doctors also report that Marinol’s high cost dissuades them from prescribing it to patients. In one survey of HIV/AIDS specialists, among respondents who had never prescribed Marinol to their patients, 33 percent cited the high cost of the drug as the reason.59 Natural cannabis, even at its inflated black market value, often remains far less costly for patients than oral synthetic THC.60

          Patients Ultimately Prefer Natural Cannabis to Marinol

          In the 1970s and 1980s, several states conducted patient trials61 of natural cannabis’ effectiveness as an anti-emetic in cancer patients unresponsive to conventional therapies. Some state protocols allowed patients to choose between inhaled cannabis62 and synthetic THC. In those studies which compared natural cannabis to dronabinol, inhaled cannabis was equal to or better than the oral administration of synthetic THC.63

          For example, researchers at the Tennessee Board of Pharmacy found a “23 percent higher success rate among those patients smoking than among those patients administered THC capsules” in the treatment of nausea and/or vomiting associated with cancer chemotherapy.64

          Researchers in New Mexico observed similar findings. “When the routes of [drug] administration were analyzed separately, it was found that inhalation was far superior to ingestion: 90.39 percent of the patients in the group that inhaled the marijuana showed improvement while only 59.65 percent of the patients in the group that orally ingested the delta-9-THC showed improvement,” they concluded.65

          Researchers at the California Board of Pharmacy found that inhaled cannabis and oral THC produced similar results in patients. However, physicians still rated natural cannabis as slightly more effective than oral THC as an anti-emetic.66

          A 1988 New York State pilot study comparing inhaled cannabis to oral THC in cancer chemotherapy patients who were unresponsive to standard antiemetic agents found: “Twenty-nine percent of patients who failed oral THC responded to the cigarette form. … Our results demonstrate that inhalation marijuana is an effective therapy for the treatment of nausea and vomiting due to cancer chemotherapy.”67

          Today, several patient populations continue to use natural cannabis and its cannabinoids in large numbers despite its illegality and the availability of Marinol. A 2005 British survey of more than 500 HIV/AIDS patients found that one-third of respondents use natural cannabis for symptomatic relief, with more than 90 percent of them reporting that it improves their appetite, muscle pain and other symptoms.68 A previous US survey found that approximately one out of four patients with HIV had used natural cannabis medicinally in the past month.69

          Cannabis use is also prevalent among patients with neurologic disorders. Nearly four out of ten Dutch patients with prescriptions for “medical grade cannabis” (cannabis provided by Dutch pharmacies with a standardized THC content of 10.2 percent) use it to treat MS or spinal cord injuries, according to survey data published in 2005 in the journal Neurology.70 Perceived efficacy is greater among respondents who inhale cannabis versus those who ingest it orally, the study found.71

          A 2002 British survey of MS patients found that 43 percent of respondents used natural cannabis therapeutically, with about half admitting they used it regularly.72 Seventy-six percent said they would do so if cannabis were legal.73 A Canadian survey of MS patients found that 96 percent of respondents were “aware cannabis was potentially therapeutically useful for MS and most (72 percent) supported [its] legalization for medicinal purposes.”74 Sixteen percent of respondents answered that they use natural cannabis for medical purposes to treat symptoms of anxiety/depression, spasticity and chronic pain.75

          A more recent Canadian survey published in Neurology reported that 14 percent of MS76 patients and 21 percent of respondents with epilepsy had used medical cannabis in the past year.77 Among epileptics, twenty-four percent of respondents said that they believed that cannabis was an effective therapy for the disease.78 A 2002 survey of patients with Parkinson’s Disease (PD) found that 25 percent of respondents had tried cannabis, with nearly half of those saying that it provided them symptomatic relief.79

          Conclusion

          Oral synthetic THC, legally available by prescription as Marinol, often provides only limited relief to a select group of patients, particularly when compared to natural cannabis and its cannabinoids. Patients often experience minimal relief from Marinol and many experience unwanted side effects. In addition, many physicians are hesitant to prescribe the drug, and some patients are unable to afford it. Despite Marinol’s legality, many patient populations continue to risk arrest and criminal prosecution to use natural cannabis medically, and most report experiencing greater therapeutic relief from it.

          The active ingredient in Marinol is a synthetic analogue of only one of the compounds in cannabis that is therapeutically beneficial to patients. By prohibiting the possession and use of natural cannabis and its cannabinoids, patients are unnecessarily burdened to use a synthetic substitute that lacks much of the therapeutic efficacy of natural cannabis and its cannabinoids.

          Marinol should remain a legal option for patients and physicians and the development of additional cannabis-based pharmaceuticals should be encouraged. However, federal and state laws should be amended to allow for those patients who are unresponsive to synthetic THC, or simply desire an alternative to oral dronabinol, the ability to use natural cannabis and its cannabinoids as a legal medical therapy without fear of arrest and/or criminal prosecution.”

          http://www.theweedblog.com/why-marinol-is-not-as-good-as-real-marijuana/

        • Marie

          That is incorrect….they do not start with cannabis. It is a CHEMICAL CONCOCTION made in a lab.

    • Guest

      here is some light reading for you
      “Marinol1 (dronabinol) is the only US FDA-approved synthetic cannabinoid. It is often marketed as a legal pharmaceutical alternative to natural cannabis.

      Marinol is manufactured as a gelatin capsule containing synthetic delta-9-tetrahydrocannabinol (THC) in sesame oil. It is taken orally and is available in 2.5mg, 5mg and/or 10mg dosages. Marinol may be prescribed for the treatment of cachexia (weight loss) in patients with AIDS and for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments.

      Despite FDA approval2, Marinol typically provides only limited relief to select patients, particularly when compared to natural cannabis and its cannabinoids. Marinol should remain a legal option for patients and physicians; however, federal and state laws should be amended to allow for those patients who are unresponsive to synthetic THC the ability to use natural cannabis and its cannabinoids as a medical therapy without fear of arrest and/or criminal prosecution. By prohibiting the possession and use of natural cannabis and its cannabinoids, patients are unnecessarily restricted to use a synthetic substitute that lacks much of the therapeutic efficacy of natural cannabis.

      Marinol Lacks Several of the Therapeutic Compounds Available in Natural Cannabis

      Chemical compounds in cannabis, known as cannabinoids, are responsible for its numerous therapeutic benefits. Scientists have identified 66 naturally occurring cannabinoids.3

      The active ingredient in Marinol, synthetic delta-9-tetrahyrdocannabinol (THC), is an analogue of one such compound, THC. However, several other cannabinoids available in cannabis — in addition to naturally occurring terpenoids (oils) and flavonoids (phenols) — have also been clinically demonstrated to possess therapeutic utility. Many patients favor natural cannabis to Marinol because it includes these other therapeutically active cannabinoids.

      For example, cannabidol (CBD) is a non-psychoactive cannabinoid that has been clinically demonstrated to have analgesic, antispasmodic, anxiolytic, antipsychotic, antinausea, and anti-rheumatoid arthritic properties.4

      Animal and human studies have shown CBD to possess anti-convulsant properties, particularly in the treatment of epilepsy.5 Natural extracts of CBD, when administered in combination with THC, significantly reduce pain, spasticity and other symptoms in multiple sclerosis (MS) patients unresponsive to standard treatment medications.6

      Clinical studies also demonstrate CBD to be neuroprotective against glutamate neurotoxicity7 (i.e. stroke), cerebral infarction8 (localized cell death in the brain), and ethanol-induced neurotoxicity,9 with CBD being more protective against glutamate neurotoxicity than either ascorbate (vitamin C) or alpha-tocopherol (vitamin E).10 Clinical trials have also shown CBD to possess anti-tumoral properties,11inhibiting the growth of glioma (brain tumor) cells in a dose dependent manner and selectively inducing apoptosis (programmed cell death) in malignant cells.12

      Additional cannabinoids possessing clinically demonstrated therapeutic properties include: cannabinol (anticonvulsant13 and anti-inflammatory14 activity); cannabichromine (anti-inflammatory15 and antidepressant16 activity); and cannabigerol (anti-tumoral17 and analgesic18 activity). Natural cannabis’ essential oil components (terpenoids) exhibit anti-inflammatory properties19 and its flavonoids possess antioxidant activity.20 Emerging clinical evidence indicates that cannabinoids may slow disease progression21 in certain autoimmune and neurologic diseases, including multiple sclerosis22 (MS), Amyotrophic Lateral Sclerosis23 (Lou Gehrig’s disease) and Huntington’s Disease.24

      Clinical data indicate that the synergism of these compounds is likely more efficacious25 than the administration of synthetic THC alone.26 For example, McPartland and Russo write: “Good evidence shows that secondary compounds in cannabis may enhance beneficial effects of THC. Other cannabinoid and non-cannabinoid compounds in herbal cannabis … may reduce THC-induced anxiety, cholinergic deficits, and immunosuppression. Cannabis terpenoids and flavonoids may also increase cerebral blood flow, enhance cortical activity, kill respiratory pathogens, and provide anti-inflammatory activity.”27 In an in vitro model of epilepsy, natural cannabis extracts performed better than THC alone.28In human trials, patients suffering from multiple sclerosis experienced greater symptomatic relief from sublingual natural cannabis extracts than from the administration of oral THC.29 In 2005, Health Canada approved the oral spray Sativex30 — which contains precise ratios of the natural cannabinoid extracts THC and CBD, among other compounds — for prescription use for MS-related symptoms.31

      Marinol is More Psychoactive Than Natural Cannabis

      Patients prescribed Marinol frequently report that its psychoactive effects are far greater than those of natural cannabis. Marinol’s adverse effects include: feeling “high,” drowsiness, dizziness, confusion, anxiety, changes in mood, muddled thinking, perceptual difficulties, coordination impairment, irritability, and depression.32 These psychoactive effects may last four to six hours.33 About one-third of patients prescribed Marinol report experiencing one or some of these adverse effects.34

      Marinol’s oral route of administration is responsible, in part, for its heightened psychoactivity compared to inhaled cannabis. Once swallowed, Marinol passes from the stomach to the small intestine before being absorbed into the bloodstream. Following absorption, Marinol passes through the liver where a significant proportion of the drug is metabolized into other chemicals.35 One of these chemicals, 11-hydroxy-THC, may be four to five times more potent than natural THC,36 and is produced in greater quantities.37 Thus, patients administered Marinol experience the psychoactive effects of both THC and 11-hydroxy-THC, greatly increasing the likelihood that they will suffer from an adverse psychological reaction. By comparison, only minute quantities of 11-hydroxy-THC are produced when cannabis is inhaled.38 Moreover, Marinol lacks the compound cannabidiol, which possesses anxiolytic activity and likely modifies and/or diminishes much of THC’s psychoactivity in natural cannabis.39

      Cannabis Vaporization Offers Advantages Over Orally Administered THC

      Vaporization is an alternative method of cannabis administration that holds distinct advantages over both smoking and oral administration. Cannabis vaporization suppresses respiratory toxins by heating cannabis to a temperature where cannabinoid vapors form (typically around 180-190 degrees Celsius), but below the point of combustion where noxious smoke and associated toxins (i.e., carcinogenic hydrocarbons) are produced (near 230 degrees Celsius).40 Although a comprehensive review of cannabis and health conducted by the National Academy of Sciences Institute of Medicine found “no conclusive evidence that marijuana causes cancer in humans, including cancers usually related to tobacco use,”41 studies have found that heavy cannabis smokers face a higher risk of contracting bronchitis and respiratory illnesses.42This risk is likely not due to the inhalation of cannabinoids, but rather to the exposure of noxious smoke. Because vaporization can deliver therapeutic doses of cannabinoids while reducing the users intake of pyrolytic smoke compounds, it is considered to be a preferred and likely safer method of cannabis administration than smoking.43

      In practice, cannabis vaporization offers considerable advantages over oral THC consumption. While the oral ingestion of Marinol avoids the potential risks of smoking, it has significant drawbacks. Because of synthetic THC’s poor bioavailability, only 5-20 percent of an oral dose ever reaches the bloodstream44 and the drug may not achieve peak effect until four hours after dosing.45 Moreover, because Marinol is metabolized slowly, its therapeutic and psychoactive effects may be unpredictable and vary considerably, both from one person to another, and in the same person from one episode of use to another.46 By contrast, cannabis vaporization delivers cannabinoids to the bloodstream almost instantaneously.47Vaporization’s rapid onset also allows patients to self regulate their dosage of cannabinoids by immediately ceasing inhalation when/if their psychoactive effects become unpleasant.48After oral administration of Marinol, patients have no choice but to experience the full psychoactive effects of the dose consumed. These dysphoric effects may last several hours.

      Because of its rapid onset, vaporized cannabis is more desirable than Marinol for patients requiring a fast-acting therapeutic agent, such as those combating oncoming attacks of nausea, seizures or muscle spasms. Cannabis vaporization also offers a unique advantage to patients suffering from nausea and vomiting because it allows them an alternative delivery route to swallowing. Cancer and HIV/AIDS patients often report that their stomachs cannot hold down Marinol capsules during bouts of severe nausea49 and many rely on natural cannabis and cannabinoids for symptom control.50 In a 1994 survey of oncologists, respondents ranked synthetic THC ninth on a list of available antiemetic medications.51In another survey of oncologists, 44 percent of respondents said that they believed natural cannabis to be more efficacious than oral synthetic THC; only 13 percent of respondents rated Marinol more effective.52 A 1997 survey of physicians found that a majority preferred megestrol acetate over Marinol as an appetite stimulant in patients with HIV/AIDS.53

      As a result of Marinol’s slow onset and poor bioavailablity, scientists are now in the process of developing a new formulation of pulmonary dronabinol, delivered with a pressurized metered dose inhaler.54 In a Phase I study, pulmonary Marinol delivered via an inhaler provided rapid systemic absorption. Unlike oral synthetic THC, it’s possible that pulmonary Marinol “could offer an alternative for patients when a fast onset of action is desirable.”55 However, FDA approval of pulmonary Marinol and/or its inhaler remains years away. Sativex, an oral cannabis spray consisting of natural cannabinoid extracts, has greater bioavailability and is faster acting than oral synthetic THC. Clinical trials comparing its bioavailability and time of peak onset compared to vaporized cannabis have not been performed, though anecdotal reports indicate that vaporized cannabis and its cannabinoids likely possess greater bioavailability and are faster acting than the Sativex spray.

      Marinol is More Expensive Than Natural Cannabis

      Synthetic THC is a costly and difficult compound to manufacture.56 Much of this cost is passed on to the patient consumer, particularly if the full cost of Marinol (approximately $200 to $800 per month,57depending on the dosage) is borne out of pocket. Patients, particularly those with chronic conditions, often report that Marinol’s market cost limits their use of the drug.58 Doctors also report that Marinol’s high cost dissuades them from prescribing it to patients. In one survey of HIV/AIDS specialists, among respondents who had never prescribed Marinol to their patients, 33 percent cited the high cost of the drug as the reason.59 Natural cannabis, even at its inflated black market value, often remains far less costly for patients than oral synthetic THC.60

      Patients Ultimately Prefer Natural Cannabis to Marinol

      In the 1970s and 1980s, several states conducted patient trials61 of natural cannabis’ effectiveness as an anti-emetic in cancer patients unresponsive to conventional therapies. Some state protocols allowed patients to choose between inhaled cannabis62 and synthetic THC. In those studies which compared natural cannabis to dronabinol, inhaled cannabis was equal to or better than the oral administration of synthetic THC.63

      For example, researchers at the Tennessee Board of Pharmacy found a “23 percent higher success rate among those patients smoking than among those patients administered THC capsules” in the treatment of nausea and/or vomiting associated with cancer chemotherapy.64

      Researchers in New Mexico observed similar findings. “When the routes of [drug] administration were analyzed separately, it was found that inhalation was far superior to ingestion: 90.39 percent of the patients in the group that inhaled the marijuana showed improvement while only 59.65 percent of the patients in the group that orally ingested the delta-9-THC showed improvement,” they concluded.65

      Researchers at the California Board of Pharmacy found that inhaled cannabis and oral THC produced similar results in patients. However, physicians still rated natural cannabis as slightly more effective than oral THC as an anti-emetic.66

      A 1988 New York State pilot study comparing inhaled cannabis to oral THC in cancer chemotherapy patients who were unresponsive to standard antiemetic agents found: “Twenty-nine percent of patients who failed oral THC responded to the cigarette form. … Our results demonstrate that inhalation marijuana is an effective therapy for the treatment of nausea and vomiting due to cancer chemotherapy.”67

      Today, several patient populations continue to use natural cannabis and its cannabinoids in large numbers despite its illegality and the availability of Marinol. A 2005 British survey of more than 500 HIV/AIDS patients found that one-third of respondents use natural cannabis for symptomatic relief, with more than 90 percent of them reporting that it improves their appetite, muscle pain and other symptoms.68 A previous US survey found that approximately one out of four patients with HIV had used natural cannabis medicinally in the past month.69

      Cannabis use is also prevalent among patients with neurologic disorders. Nearly four out of ten Dutch patients with prescriptions for “medical grade cannabis” (cannabis provided by Dutch pharmacies with a standardized THC content of 10.2 percent) use it to treat MS or spinal cord injuries, according to survey data published in 2005 in the journal Neurology.70 Perceived efficacy is greater among respondents who inhale cannabis versus those who ingest it orally, the study found.71

      A 2002 British survey of MS patients found that 43 percent of respondents used natural cannabis therapeutically, with about half admitting they used it regularly.72 Seventy-six percent said they would do so if cannabis were legal.73 A Canadian survey of MS patients found that 96 percent of respondents were “aware cannabis was potentially therapeutically useful for MS and most (72 percent) supported [its] legalization for medicinal purposes.”74 Sixteen percent of respondents answered that they use natural cannabis for medical purposes to treat symptoms of anxiety/depression, spasticity and chronic pain.75

      A more recent Canadian survey published in Neurology reported that 14 percent of MS76 patients and 21 percent of respondents with epilepsy had used medical cannabis in the past year.77 Among epileptics, twenty-four percent of respondents said that they believed that cannabis was an effective therapy for the disease.78 A 2002 survey of patients with Parkinson’s Disease (PD) found that 25 percent of respondents had tried cannabis, with nearly half of those saying that it provided them symptomatic relief.79

      Conclusion

      Oral synthetic THC, legally available by prescription as Marinol, often provides only limited relief to a select group of patients, particularly when compared to natural cannabis and its cannabinoids. Patients often experience minimal relief from Marinol and many experience unwanted side effects. In addition, many physicians are hesitant to prescribe the drug, and some patients are unable to afford it. Despite Marinol’s legality, many patient populations continue to risk arrest and criminal prosecution to use natural cannabis medically, and most report experiencing greater therapeutic relief from it.

      The active ingredient in Marinol is a synthetic analogue of only one of the compounds in cannabis that is therapeutically beneficial to patients. By prohibiting the possession and use of natural cannabis and its cannabinoids, patients are unnecessarily burdened to use a synthetic substitute that lacks much of the therapeutic efficacy of natural cannabis and its cannabinoids.

      Marinol should remain a legal option for patients and physicians and the development of additional cannabis-based pharmaceuticals should be encouraged. However, federal and state laws should be amended to allow for those patients who are unresponsive to synthetic THC, or simply desire an alternative to oral dronabinol, the ability to use natural cannabis and its cannabinoids as a legal medical therapy without fear of arrest and/or criminal prosecution.”

      http://www.theweedblog.com/why-marinol-is-not-as-good-as-real-marijuana/

  • Corinne

    This articles talks about Stan Rutner. This is my father and her is still cancer free 3+years later. His coconut capsules are unique as they do not have Cannabis oil in them. They are simply cannabis and coconut oil capsules. We have seen many people benefit from these capsules. Here is the link to my dad’s story and our company that was built through his journey.
    Dad isnow 81. He travels, takes strength and balance classes and is one happy guy!
    Best,
    ~Corinne Malanca
    http://www.unitedpatientsgroup.com/blog/2013/09/07/cannabis-oil-convinced-of-the-cure/

  • Robert Ireland

    smh, everyone wants to call this medicine. Everybody only ever talks about 2 out of the 525 different compounds of this amazing plant. Nobody seems to understand that if this were a part of both our daily diets and in our food chain, we would likely never even get most if not almost all of these horrendous diseases and there IS quite some precedence for this all around the world in micro-cultures we’re seeing. This plant affects EVERYONE. Not just the the sick. EVERYONE and EVERY VERTEBRATE ANIMAL ON THE PLANET. What we are seeing seems to indicate those who retained it in their food chain live to well over 90 in near perfect health and those who consume it directly as a regular part of their diet are living into their 110s and 120s in near perfect health. Oldest passed last year in China, she was 126 years old and just recently in India, and she was 125 years. IS anyone seeing the bigger picture here, yet. Medicine AFTER the fact of a massive and multi-generational nutrient deficiency of over 85 cannabinoids, more than 120 terpenes and a host of other nutrients, both most of the known and accepted 48 or so, plus about 10 times more yet to be announced. It is even being debated if vitamins A, C(a terpene), D3, K1 and K2 aren’t also cannabinoids. Plus, the part of the story they are not telling you about the Omega Fats, particularly Omega 3, is that when it breaks down in about the 3rd stage of compounds, anadamide is produced from it. About another 5 steps and it becomes progesterone. Assholes are STILL trying to drive the debate with this divisive CBD vs THC non-debate, because we also know those two work best TOGETHER and along with all the other 523 compounds, it becomes THE ASSKICKER FOOD of ALL FOODS.

    • Steven Bristow

      Well said Robert.
      I always say #wholeplantmedicine is the best medicine.

    • Winston Sharpe

      So they told me back in the late 60’s that my children could be born with birth defects, had 5 kids and each birth freaked me out because of the bullshit propaganda spread to demonize weed, lucky for me all kids were normal but cant decribe what the lies did to my head. F@#&k the drug war !!!

    • Maribel Crider

      bravo Robert

  • http://www.weed.co.za Chris Jay

    Customers are very happy with results of cannacaps and cannabalm http://www.nguniseeds.com/store

  • Bill Williams

    Doesn’t matter what kind of oil. Oil extracts cannabinoids.

  • Corinne

    Patients needs both thc and CBD to fight cancer. Marinol is a synthetic version of thc to induce appetite and to combat nausea. Marinol can take up to 6 weeks to see an increase in appetite. My dad had 2 weeks max. Time was not on our side.
    Thankfully the coconut oil and cannabis capsule worked. It is only 7mg and we cut it into quarters. He took 1/4 per day. I feel that the aversion to this viable treatment is based on fear. Yet it is the pharmaceuticals that can wreak havoc on our bodies.
    Education is key. This is why my company (built from my father’s journey you read above) offers CME courses in cannabinoid therapeutics. These are science based courses.
    Please take a look!
    http://Www.UnitedPatientsGroup.com

  • Rhea Graham

    Learn more about Smokeless Cannabis Remedies that are available at http://www.cannakitchenandresearch.com/product-information.html

  • noservicesnoco

    This article has ZERO shares becuz it has no real info for ppl…there are several links to follow, but those also do NOT provide REAL info…like HOW to obtain or make these coconut oil X cannabis capsules.

  • http://www.thewizardofrockandroll.blogspot.com/ thewizardofrockandroll

    I get angrier as I see friends of Mine dying from the curse of Cancer , when many of those with the Big C might have been saved , if only the A-Holes in the DEA would stop Bullshitting the American peopole and let the God given drug and possible cure to so many ailments if only these people worried more about its Citizens lives , then their Kick Backs and phony excuses to keep The Weed as a method to enslave members of certain races , imprisoning them so they can keep their jobs that wastes more and more Billions of $ every year , on a Losing battle. Even tho so many Medical practitioners and Scientists for years have urged the decriminalization of Marijuana , still the DEA will not relent . So that means its time to 86 the DEA’s power when it comes to the Category Listing of POT as a Category 1 , no medical use Drug.
    For their total ignoring to so many facts , it has become more then losing Agents ( arent there enough other Drugs to keep them working or is it the loss of Millions , maybe Billions of $ in their pockets from the people who keep paying off the agents to keep Weed illegal , so they all can capitalize on it. Instead of the Benefits all the people in the World might benefit from Pot ,if the Studies were made w/o any BS RED Tape ; as their is still the DEA controlling it for themselves !
    That must be ended , or they should all be fired for ignoring the studies and polls that more then show the majority of People , want to see that BS Changed ! Please spread the word , its illegal to keep a Cure away , while other people make gigantic profits keeping it Category 1 ! All you anti Weed people , why is HEMP a non-drug containing sister of Marijuana , that has no use except its benefits to our Environment was made illegal , so the PLASTIC Suits can push their polluting products on our Planet ! All those who want weed banned , do it cause they get Money off of it some how or some way keeping it Illegal !

Close
Like us. You won’t regret it.
We post stuff just like this every day on Facebook